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Cell-penetrating peptides in glioma Regarding the impermeability of the BBB and cell membrane to therapeutic macromolecules (of large size and low permeability), the incorporation of CPPs, which increase the crossing of the BBB and plasma membrane in peptide-based drug delivery systems, can be a clever solution

Treatment with AAV-P125A-endostatin in combination with carboplatin resulted in 60% of the animals remaining tumor-free for over 200 days, which was significantly better than treatment with AAV-vehicle and/or carboplatin alone [123]

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